Beilstein Arch. 2026, 202616. https://doi.org/10.3762/bxiv.2026.16.v1
Published 29 Apr 2026
A new bicyclic metabolite, rhodopyran (1), was isolated from the culture broth of Rhodococcus sp. strain RD066637. The planar structure was elucidated by 1D/2D NMR analyses and HRMS spectrometry, and the relative configuration was assigned from vicinal coupling constants and NOESY correlations, while the absolute configuration remains undetermined. Rhodopyran represents a structurally unusual carboxylated hexahydrocyclopenta[b]pyran and expands the known metabolite diversity of Rhodococcus, highlighting this underexplored genus as a source of uncommon natural-product scaffolds.
Keywords: compound; cyclopenta[b]pyran; natural products; Rhodococcus; secondary metabolites
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Harunari, E.; Fushimi, S.; Igarashi, Y. Beilstein Arch. 2026, 202616. doi:10.3762/bxiv.2026.16.v1
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