Acremochlorin O and Other Prenylated Chlorophenol Antimicrobial Metabolites from the Fungus Acremonium sp. Strain MNA-F-1

Submitting author affiliation:
Faculty of Pharmacy, Ain Shams University, Cairo, Egypt

Beilstein Arch. 2024, 202422.

Published 15 Apr 2024

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This preprint has not been peer-reviewed. When a peer-reviewed version is available, this information will be updated.


Chemical investigation of the ethyl acetate extract of the fungus Acremonium sp., derived from the inner tissue of anise roots, led to the isolation and characterization of one new chlorinated compound, acremochlorin O (1), together with five related derivatives (26) and an alkaloidal metabolite, ilicicolin H (7). Structure elucidation of the isolated compounds was determined based on extensive 1D/2D NMR spectroscopic analyses and HR-ESI-MS measurements. The absolute configuration of acremochlorin O (1) was established using an electronic circular dichroism (ECD) experiment. All isolated compounds were evaluated for their antibacterial activity against Staphylococcus aureus, Escherichia coli and Mycobacterium tuberculosis, where several compounds revealed potent activities against tested Gram-positive strains.

Keywords: Fungal endophyte; Acremonium sp.; prenylated chlorophenols; antitubercular

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When a peer-reviewed version of this preprint is available, this information will be updated in the information box above. If no peer-reviewed version is available, please cite this preprint using the following information:

Elnaggar, M. S.; Mostafa, N. M.; Elissawy, A. M.; Phutthacharoen, K.; Eckhardt, P.; Sandargo, B.; van Geelen, L.; Ebada, S. S.; Opatz, T.; Singab, A. N. B.; Kalscheuer, R. Beilstein Arch. 2024, 202422. doi:10.3762/bxiv.2024.22.v1

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