Five new sesquiterpenoids from the agarwood of Aquilaria sinensis

Submitting author affiliation:
Southwest Jiaotong University, Chengdu, China

Beilstein Arch. 2023, 202313.

Published 11 Apr 2023

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Aquisinenoids F–G (15), five new eudesmane-type sesquiterpenoids, and five known compounds (610) were isolated from the agarwood of Aquilaria sinensis. Their structures, including absolute configurations were unambiguously identified by comprehensive spectroscopic analyses and computational methods. Inspiring by our previous study on the same kind of skeletons, the bioactive studies of all new compounds were carried towards anti-cancer and anti-inflammatory activity. The results do not show any activity but it revealed the structure-activity relationships (SAR).

Keywords: Aquilaria sinensis; agarwood; sesquiterpenoids; SAR studies

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Zhou, H.; Li, X.-Y.; Fang, B.-H.; Jiang, H.-Z.; Cheng, Y.-X. Beilstein Arch. 2023, 202313. doi:10.3762/bxiv.2023.13.v1

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