Secondary metabolites of Diaporthe sp., isolated from the Cameroonian medicinal plant Trema guineensis (Schumach. & Thonn.) Ficalho

Bel Youssouf G. Mountessou; Elodie Gisele Mouafo Anoumedem; Blondelle Matio Kemkuignou; Yasmina Marin-Felix; Frank Surup; Marc Stadler; Simeon Fogue Kouam

doi:10.3762/bxiv.2023.12.v1

Secondary metabolites of Diaporthe sp., isolated from the Cameroonian medicinal plant Trema guineensis (Schumach. & Thonn.) Ficalho

Bel Youssouf G. Mountessou ,
Elodie Gisele Mouafo Anoumedem ,
Blondelle Matio Kemkuignou ,
Yasmina Marin-Felix ,
Frank Surup ,
Marc Stadler and
Simeon Fogue Kouam

Submitting author affiliation:

Higher Teacher Training College, University of Yaounde 1, Yaounde, Cameroon

Beilstein Arch. 2023, 202312. https://doi.org/10.3762/bxiv.2023.12.v1

Published 11 Apr 2023

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Read the peer-reviewed version of this preprint: https://doi.org/10.3762/bjoc.19.112

SUBJECT AREAS

Show All Preprints Nanotechnology Organic chemistry Bioorganic chemistry / chemical biology Catalysis Chemical methods and reactions Flow and process chemistry Green and sustainable chemistry Materials chemistry Medicinal and pharmaceutical chemistry Nano- and molecular-scale electronics Nano-biomaterials and bioscience Nanomagnetics Nanomaterials, thin films and nanointerfaces Nanomedicine Nanometrology and nanomechanics Nano-optics Nanopatterning, self-assembly and nanofabrication Nanostructures for energy and sensing applications Natural products chemistry Organo main group chemistry Other nanotechnology (unclassified) Other organic chemistry (unclassified) Photochemistry and photovoltaics Physical organic chemistry Supramolecular chemistry

Abstract

From a fresh root of Trema guineensis (Ulmaceae), endophytic fungi were isolated, among which a taxon belonging to Diaporthe sp. This strain was fermented in shake flask batch cultures and the broth extracted with ethyl acetate. From the crude extract, a hemiketal polyketide (1), and an acetylated alternariol (2) were isolated, along with fifteen known secondary metabolites. Their structures were established by extensive NMR spectroscopy and mass spectrometry analyses, as well as by comparison with literature data of their analogs.

Keywords: Diaporthe, Endophytic fungi, Hemiketal polyketide, Alternariol

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Mountessou, B. Y. G.; Anoumedem, E. G. M.; Kemkuignou, B. M.; Marin-Felix, Y.; Surup, F.; Stadler, M.; Kouam, S. F. Beilstein Arch. 2023, 202312. doi:10.3762/bxiv.2023.12.v1

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aromatic	the word “aromatic”
aromatic aldehyde	the word “aromatic” OR “aldehyde”
+aromatic +aldehyde	both words “aromatic” AND “aldehyde”
+aromatic -aldehyde	the word “aromatic” but NOT “aldehyde”
“aromatic aldehyde”	the exact phrase “aromatic aldehyde”
benz*	words which begin with “benz”, such as “benzene” or “benzyl”
benz*yl	words that begin with “benz” and end with “yl”, such as “benzyl” or “benzoyl”
benzyl~	words that are close to the word “benzyl”, such as “benzoyl” (i.e., fuzzy search)