Non-peptide compounds from Kromopolites svenhedini (Verhoeff) and their anti-tumor and iNOS inhibitory activities

Submitting author affiliation:
Shenzhen University, Shenzhen, China

Beilstein Arch. 2023, 202311.

Published 06 Apr 2023

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Six new compounds, including one tetralone (1), two xanthones (2 and 3), one flavan derivative (4), and two nor-diterpenoids (7 and 8), with two known flavan derivatives (5 and 6) and one known olefine acid (9) were isolated from the whole bodies of Kromopolites svenhedini (Verhoeff). All the structures of new compounds were determined by 1D and 2D nuclear magnetic resonance (NMR) and other spectroscopic methods, as well as computational methods. Part of the compounds were evaluated for their biological properties against the mouse pancreatic cancer cell line and inhibitory effects on iNOS and COX-2.

Keywords: Kromopolites svenhedini (Verhoeff); arthropod; non-peptide small molecules; anti-tumor; iNOS

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Yuan, Y.-N.; Li, J.-Q.; Fang, H.-B.; Xing, S.-J.; Yan, Y.-M.; Cheng, Y.-X. Beilstein Arch. 2023, 202311. doi:10.3762/bxiv.2023.11.v1

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