Terpenoids from Glechoma hederacea var. longituba and Their Biological Activities

Submitting author affiliation:
Sungkyunkwan university, school of pharmacy, Suwon, Korea, Republic of

Beilstein Arch. 2022, 20221. https://doi.org/10.3762/bxiv.2022.1.v1

Published 05 Jan 2022

cc-by Logo


Glechoma hederacea var. longituba (common name: ground-ivy) has been used for the treatment of asthma, bronchitis, cholelithiasis, colds, and inflammation. In the present study, three new sesquiterpene glycosides (13), two new diterpene glycosides (45), and four known compounds (69) were isolated from its MeOH extract. Structure elucidation was performed for the five new compounds (15) using 1D and 2D NMR, HRESIMS, ECD calculation, and chemical methods. All the isolates (19) were assessed for their anti-neuroinflammatory activity on nitric oxide (NO) production in lipopolysaccharide (LPS)-activated BV-2 cells, nerve growth factor (NGF) secretion stimulation activity in C6 glioma cells, and cytotoxic activity against four human cancer cell lines (A549, SK-OV-3, SK-MEL-2, and HCT15). Compounds 2 and 57 exhibited inhibitory effects on NO production with IC50 values of 52.21, 47.90, 61.61, and 25.35 μM, respectively. Compound 5 also exhibited a significant stimulating effect on NGF secretion (122.77 ± 8.10%). Compound 9 showed potent cytotoxic activity against SK-OV-3 (IC50 3.76 μM) and SK-MEL-2 (IC50 1.48 μM) cell lines, while 7 displayed a strong cytotoxic activity against SK-MEL-2 (IC50 9.81 μM) cell line

Keywords: Glechoma hederacea var. longituba; Terpenoid; Anti-neuroinflammation; Neurotrophic effect; Cytotoxicity.

Supporting Information

Format: DOCX Size: 3.3 MB   Download

How to Cite

When a peer-reviewed version of this preprint is available, this information will be updated in the information box above. If no peer-reviewed version is available, please cite this preprint using the following information:

Kim, D. H.; Khan, Z.; Kim, S. Y.; Choi, S. U.; Kim, C. S.; Lee, K. R. Beilstein Arch. 2022, 20221. doi:10.3762/bxiv.2022.1.v1

Download Citation

Citation data can be downloaded as file using the "Download" button or used for copy/paste from the text window below.
Citation data in RIS format can be imported by all major citation management software, including EndNote, ProCite, RefWorks, and Zotero.