First Total Synthesis of Hoshinoamides A  

  1. Haipin ZhouORCID Logo,
  2. Zihan Rui,
  3. Yiming Yang,
  4. Shengtao Xu,
  5. Yutian Shao and
  6. Long LiuORCID Logo

Submitting author affiliation: Chuzhou University, Chuzhou City, Anhui Province, China

Beilstein Arch. 2021, 202164. https://doi.org/10.3762/bxiv.2021.64.v1

Published 15 Sep 2021

  • Preprint

Abstract

Hoshinoamides A, B and C, linear lipopeptides, were isolated from the marine cyanobacterium Caldora penicillata, with potent antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum. Herein, we describe the first total synthesis of Hoshinoamides A. Our synthetic strategy uses the combined methods of solution and solid phase peptide synthesis. Liquid phase synthesis is to improve the coupling yield of L-Val3 and N-Me-D-Phe2. Connecting other amino acids efficiency and convergence by solid state synthesis. This synthetic strategy has good purity and high yield.

Keywords: highly methylated polypeptides;  Hoshinoamides;  total synthesis;  antimalarial

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When a peer-reviewed version of this preprint is available, this information will be updated in the information box above. If no peer-reviewed version is available, please cite this preprint using the following information:

Zhou, H.; Rui, Z.; Yang, Y.; Xu, S.; Shao, Y.; Liu, L. Beilstein Arch. 2021, 202164. doi:10.3762/bxiv.2021.64.v1

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