Copper-Mediated Oxidative C−H/N−H Activations with Alkynes by Removable Hydrazides

  1. Feng Xiong,
  2. Bo Li,
  3. Chenrui Yang,
  4. Liang Zou,
  5. Wenbo MaORCID Logo,
  6. Linghui GuORCID Logo,
  7. Ruhuai MeiORCID Logo and
  8. Lutz AckermannORCID Logo

Submitting author affiliation: Chengdu University, Chengdu, China

Beilstein Arch. 2021, 202139. https://doi.org/10.3762/bxiv.2021.39.v1

Published 21 May 2021

  • Preprint

Abstract

The efficient copper-mediated oxidative C–H alkynylaiton of benzhydrazides was accomplished with terminal alkynes. Thus, a hetero-aromatic removable N-2-pyridylhydrazide allowed for domino C–H/N–H functionalization. The approach featured remarkable functional group compatibility and ample substrates scope. Thereby, highly functionalized aromatic and hetero-aromatic isoindolin-1-ones were accessed with high efficacy with rate-limiting C–H cleavage.

Keywords: copper; benzhydrazides; 3-methyleneisoindolin-1-one; removable directing group

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When a peer-reviewed version of this preprint is available, this information will be updated in the information box above. If no peer-reviewed version is available, please cite this preprint using the following information:

Xiong, F.; Li, B.; Yang, C.; Zou, L.; Ma, W.; Gu, L.; Mei, R.; Ackermann, L. Beilstein Arch. 2021, 202139. doi:10.3762/bxiv.2021.39.v1

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