Copper-Mediated Oxidative C−H/N−H Activations with Alkynes by Removable Hydrazides

Submitting author affiliation:
Chengdu University, Chengdu, China

Beilstein Arch. 2021, 202139. https://doi.org/10.3762/bxiv.2021.39.v1

Published 21 May 2021

Preprint
cc-by Logo

Abstract

The efficient copper-mediated oxidative C–H alkynylaiton of benzhydrazides was accomplished with terminal alkynes. Thus, a hetero-aromatic removable N-2-pyridylhydrazide allowed for domino C–H/N–H functionalization. The approach featured remarkable functional group compatibility and ample substrates scope. Thereby, highly functionalized aromatic and hetero-aromatic isoindolin-1-ones were accessed with high efficacy with rate-limiting C–H cleavage.

Keywords: copper; benzhydrazides; 3-methyleneisoindolin-1-one; removable directing group

Supporting Information

Format: PDF Size: 6.3 MB   Download

How to Cite

When a peer-reviewed version of this preprint is available, this information will be updated in the information box above. If no peer-reviewed version is available, please cite this preprint using the following information:

Xiong, F.; Li, B.; Yang, C.; Zou, L.; Ma, W.; Gu, L.; Mei, R.; Ackermann, L. Beilstein Arch. 2021, 202139. doi:10.3762/bxiv.2021.39.v1

Download Citation

Citation data can be downloaded as file using the "Download" button or used for copy/paste from the text window below.
Citation data in RIS format can be imported by all major citation management software, including EndNote, ProCite, RefWorks, and Zotero.

OTHER BEILSTEIN-INSTITUT OPEN SCIENCE ACTIVITIES