Organocatalytic Asymmetric Michael/Acyl Transfer Reaction between α-Nitroketones and 4-Arylidene- pyrrolidine-2,3-diones

  1. Chandrakanta ParidaORCID Logo and
  2. Subhas C PanORCID Logo

Submitting author affiliation: Department of Chemistry, Indian Institute of Technology Guwahati, North Guwahati, Assam, 781039, Guwahati, India

Beilstein Arch. 2021, 202128.

Published 23 Mar 2021

  • Preprint


An organocatalytic asymmetric Michael/acyl transfer reaction between α-nitroketones and 4-arylidene-pyrrolidine-2,3-diones was reported. Bifunctional thiourea catalyst was found to be effective for this reaction. With 10 mol% of the catalyst, good results were attained for a variety of 1,5-dihydro-2H-pyrrol-2-ones under mild reaction conditions.

Keywords: Michael reaction, acyl transfer, pyrrolidine-2,3-diones, organocatalysis, enantioselectivity

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Parida, C.; Pan, S. C. Beilstein Arch. 2021, 202128. doi:10.3762/bxiv.2021.28.v1

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