Metal-free visible-light-enabled vicinal trifluoromethyl dithiolation of unactivated alkenes

  1. Xiaojuan Li,
  2. Qiang Zhang,
  3. Weigang Zhang,
  4. Jinzhu MaORCID Logo,
  5. Yi WangORCID Logo and
  6. Yi Pan

Submitting author affiliation: Nanjing University, Nanjing, China

Beilstein Arch. 2021, 20211.

Published 13 Jan 2021

  • Preprint


The difunctionalization of alkenes involving trifluoromethylthio group (SCF3) for the conversion of versatile and readily available olefins into more structurally complex molecules has been greatly studied. However, the disproportionate dithiolation of alkene is unknown. Herein, a transition-metal-free protocol is presented for vicinal trifluoromethylthio-thiolation of unactivated alkenes via a radical process under mild condition with broad substrate scope and excellent tolerance.

Keywords: metal-free, photoredox, difunctionalization, trifluoromethylthiolation, alkenes.

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Li, X.; Zhang, Q.; Zhang, W.; Ma, J.; Wang, Y.; Pan, Y. Beilstein Arch. 2021, 20211. doi:10.3762/bxiv.2021.1.v1

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