In this study, we investigated host–guest interactions between Oroxin A (OA) and cucurbituril (Q) using 1H NMR, MS, UV-Vis and IR spectroscopy. The results showed that OA and Q formed an inclusion compound (OA@Q) with a molar ratio of 1:1 and a binding constant of 1.299 × 107 L·mol−1. In addition, the effect of Q on the properties of OA was investigated through comparative experiments. The solubility of OA in water increased 22.47-fold when the concentration of Q was 1 × 10−4 mol·L−1. Q hardly affected the antioxidant capacity of OA, while the cumulative release of OA in gastric juice increased 2.3-fold after forming the inclusion compound with Q.
Keywords: Oroxin A; Cucurbituril; Host-guest interaction; Inclusion complex; Properties
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When a peer-reviewed version of this preprint is available in the Beilstein Journals, this information will be updated in the information box above. If no peer-reviewed version is available, please cite this preprint using the following information:
Zeng, Z.; Xie, J.; Luo, G.; Tao, Z.; Zhang, Q. Beilstein Arch. 2020, 202081. doi:10.3762/bxiv.2020.81.v1
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