Metal-free synthesis of phosphinoylchroman-4-ones via phosphinoylation/cyclization cascade mediated by K2S2O8

  1. Qiang LiuORCID Logo,
  2. Weibang Lu,
  3. Guanqun Xie and
  4. Xiaoxia Wang

Submitting author affiliation: Dongguan University of Technology, Dongguan, China

Beilstein Arch. 2020, 202071. https://doi.org/10.3762/bxiv.2020.71.v1

Published 10 Jun 2020

  • Preprint

Abstract

A variety of chroman-4-ones bearing phosphine oxide motifs were conveniently synthesized from readily available diphenylphosphine oxide and alkenyl aldehydes via a metal-free tandem phosphinoylation/cyclization protocol. The reaction utilizes K2S2O8 as oxidant and proceeds in DMSO-H2O at environmentally benign conditions with broad substrate scope and afforded the title compounds in moderate yields.

Keywords: chroman-4-ones; diphenylphosphine oxide; potassium persulfate; metal-free; radical cyclization

Supporting Information

Format: DOCX Size: 2.6 MB   Download

How to Cite

When a peer-reviewed version of this preprint is available, this information will be updated in the information box above. If no peer-reviewed version is available, please cite this preprint using the following information:

Liu, Q.; Lu, W.; Xie, G.; Wang, X. Beilstein Arch. 2020, 202071. doi:10.3762/bxiv.2020.71.v1

Download Citation
Download RIS (Reference Manager) Download BIB (BIBTEX)

© 2020 Liu et al.; licensee Beilstein-Institut.
This is an Open Access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0). Please note that the reuse, redistribution and reproduction in particular requires that the authors and source are credited.
The license is subject to the Beilstein Archives terms and conditions: (https://www.beilstein-archives.org/xiv/terms)

Other Beilstein-Institut Open Science Activities

Logo
Logo
Logo
Symposia