Decarboxylative Bromination of Thiazole Core and Consecutive Cross-Coupling Reactions

  1. Emma FreibergerORCID Logo,
  2. Eric Täuscher,
  3. Uwe RitterORCID Logo,
  4. Nadine Eckert and
  5. Helmar Görls

Submitting author affiliation: Technische Universität Ilmenau, Ilmenau, Germany

Beilstein Arch. 2020, 202027. https://doi.org/10.3762/bxiv.2020.27.v1

Published 13 Mar 2020

  • Preprint

Abstract

The 2,5-substituted 4-hydroxythiazoles form a fluorescent dye class with wide-range-tunable absorption and emission wavelengths. The insights gained on these heterocyclic fluorescence systems are intended to contribute to the development of alternative applications of such molecules in the various areas of biology, chemistry and technology. Therefore, a synthesis strategy for the bromination of the thiazole core was developed, which allows the implementation of various cross-coupling reactions on thiazoles. Furthermore, the so formed conjugated cross-coupling products are highly fluorescent and were investigated in terms of their spectroscopic properties.

Keywords: etherification; fluorescence; heterocycles; Hunsdiecker reaction; thiazole.

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When a peer-reviewed version of this preprint is available, this information will be updated in the information box above. If no peer-reviewed version is available, please cite this preprint using the following information:

Freiberger, E.; Täuscher, E.; Ritter, U.; Eckert, N.; Görls, H. Beilstein Arch. 2020, 202027. doi:10.3762/bxiv.2020.27.v1

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