A Sustainable Strategy for the Straightforward Preparation of 2H-azirines and Highly Functionalized NH-aziridines from Vinyl Azides Using a Single Solvent Flow-Batch Approach

  1. Michael AndresiniORCID Logo,
  2. Leonardo Degennaro and
  3. Renzo LuisiORCID Logo

Submitting author affiliation: University of Bari, Bari, Italy

Beilstein Arch. 2020, 2020130. https://doi.org/10.3762/bxiv.2020.130.v1

Published 16 Nov 2020

  • Preprint

Abstract

The reported flow-batch approach enables the easy preparation of 2H-azirines and their stereoselective transformation into highly functionalized NH-aziridines, starting from vinyl azides and organolithiums. The protocol has been developed using cyclopentylmethylether (CPME) as an environmentally responsible solvent, resulting into a sustainable, safe and potentially automatable method for the synthesis of interesting strained compounds.

Keywords: 2H-Azirines; Aziridines; Organolithiums; Flow Chemistry; Green Chemistry

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When a peer-reviewed version of this preprint is available, this information will be updated in the information box above. If no peer-reviewed version is available, please cite this preprint using the following information:

Andresini, M.; Degennaro, L.; Luisi, R. Beilstein Arch. 2020, 2020130. doi:10.3762/bxiv.2020.130.v1

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