1,3-Dipolar Cycloadditions of Isatin N,N′‑Cyclic Azomethine Imines with Alkynes for the synthesis of spiro[indoline-3,1'-pyrazolo[1,2-a]pyrazoles]

  1. Yang Shi,
  2. Gangqiang Wang,
  3. Zhiyu Chen,
  4. Minghu Wu,
  5. Jian Wang,
  6. Leslie Trigoura,
  7. Haibing Guo,
  8. Yalan XingORCID Logo and
  9. Shaofa Sun

Submitting author affiliation: William Paterson University of New Jersey, Wayne, United States

Beilstein Arch. 2019, 201963. https://doi.org/10.3762/bxiv.2019.63.v1

Published 08 Jul 2019

  • Preprint


CuCO3 catalyzed 1, 3-dipolar cycloaddition of isatin N,N′‑cyclic azomethine imine has been developed.  Biologically active heterocyclic spiro[indoline-3,1'-pyrazolo[1,2-a]pyrazoles] were prepared as single regioisomers in good yields and functional group compatibility.

Keywords: cycloaddition isatin N,N′‑Cyclic Azomethine Imines heterocycles 1,3-Dipolar

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Shi, Y.; Wang, G.; Chen, Z.; Wu, M.; Wang, J.; Trigoura, L.; Guo, H.; Xing, Y.; Sun, S. Beilstein Arch. 2019, 201963. doi:10.3762/bxiv.2019.63.v1

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