1,3-Dipolar Cycloadditions of Isatin N,N′‑Cyclic Azomethine Imines with Alkynes for the synthesis of spiro[indoline-3,1'-pyrazolo[1,2-a]pyrazoles]

Yang Shi; Gangqiang Wang; Zhiyu Chen; Minghu Wu; Jian Wang; Leslie Trigoura; Haibing Guo; Yalan Xing; Shaofa Sun

doi:10.3762/bxiv.2019.63.v1

1,3-Dipolar Cycloadditions of Isatin N,N′‑Cyclic Azomethine Imines with Alkynes for the synthesis of spiro[indoline-3,1'-pyrazolo[1,2-a]pyrazoles]

Yang Shi ,
Gangqiang Wang ,
Zhiyu Chen ,
Minghu Wu ,
Jian Wang ,
Leslie Trigoura ,
Haibing Guo ,
Yalan Xing and
Shaofa Sun

Submitting author affiliation:

William Paterson University of New Jersey, Wayne, United States

Beilstein Arch. 2019, 201963. https://doi.org/10.3762/bxiv.2019.63.v1

Published 08 Jul 2019

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Show All Preprints Nanotechnology Organic chemistry Bioorganic chemistry / chemical biology Catalysis Chemical methods and reactions Flow and process chemistry Green and sustainable chemistry Materials chemistry Medicinal and pharmaceutical chemistry Nano- and molecular-scale electronics Nano-biomaterials and bioscience Nanomagnetics Nanomaterials, thin films and nanointerfaces Nanomedicine Nanometrology and nanomechanics Nano-optics Nanopatterning, self-assembly and nanofabrication Nanostructures for energy and sensing applications Natural products chemistry Organo main group chemistry Other nanotechnology (unclassified) Other organic chemistry (unclassified) Photochemistry and photovoltaics Physical organic chemistry Supramolecular chemistry

Abstract

CuCO₃ catalyzed 1, 3-dipolar cycloaddition of isatin N,N′‑cyclic azomethine imine has been developed. Biologically active heterocyclic spiro[indoline-3,1'-pyrazolo[1,2-a]pyrazoles] were prepared as single regioisomers in good yields and functional group compatibility.

Keywords: cycloaddition isatin N,N′‑Cyclic Azomethine Imines heterocycles 1,3-Dipolar

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When a peer-reviewed version of this preprint is available, this information will be updated in the information box above. If no peer-reviewed version is available, please cite this preprint using the following information:

Shi, Y.; Wang, G.; Chen, Z.; Wu, M.; Wang, J.; Trigoura, L.; Guo, H.; Xing, Y.; Sun, S. Beilstein Arch. 2019, 201963. doi:10.3762/bxiv.2019.63.v1

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aromatic	the word “aromatic”
aromatic aldehyde	the word “aromatic” OR “aldehyde”
+aromatic +aldehyde	both words “aromatic” AND “aldehyde”
+aromatic -aldehyde	the word “aromatic” but NOT “aldehyde”
“aromatic aldehyde”	the exact phrase “aromatic aldehyde”
benz*	words which begin with “benz”, such as “benzene” or “benzyl”
benz*yl	words that begin with “benz” and end with “yl”, such as “benzyl” or “benzoyl”
benzyl~	words that are close to the word “benzyl”, such as “benzoyl” (i.e., fuzzy search)