Synthesis of multi-substituted indene derivatives from aryl, vinyl, and alkyl/aryl carbinols

Submitting author affiliation:
CSIR-Indian Institute of Chemical Technology, Hyderabad, India

Beilstein Arch. 2019, 201939.

Published 07 Jun 2019

This preprint has not been peer-reviewed. When a peer-reviewed version is available, this information will be updated.


A divergent approach to highly substituted functionalized indenes has been developed. The two-step reaction involving nucleophilic addition reaction of aryl vinyl ketone, an ideal intermediate with aryl or alkyl nucleophilic reagent, followed by electrocyclization (Nazarov cyclization) in the presence of Lewis acid catalyst afforded indene derivatives in good to excellent yield.

Keywords: Aryl vinyl ketones; Electrocyclization; Indene derivatives; Nazarov cyclization; Nazarov cyclization precursors 

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When a peer-reviewed version of this preprint is available, this information will be updated in the information box above. If no peer-reviewed version is available, please cite this preprint using the following information:

Chakraborty, M.; Mahesh, G.; Nakel, O. R.; Chavda, G.; Anusha, S.; Sudhakar, G. Beilstein Arch. 2019, 201939. doi:10.3762/bxiv.2019.39.v1

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