Efficient Method for Propargylation of Aldehydes Promoted by Allenyl Boron Compounds under Microwave Irradiation

  1. Jucleiton JR Freitas,
  2. Queila PSB Freitas,
  3. Silvia RCP Andrade,
  4. Juliano CR Freitas,
  5. Roberta A Oliveira and
  6. Paulo H MenezesORCID Logo

Submitting author affiliation: Universidade Federal de Pernambuco, Recife, Brazil

Beilstein Arch. 2019, 2019138. doi:10.3762/bxiv.2019.138.v1

Published 01 Nov 2019

  • Preprint

Abstract

The propargylation of aldehydes promoted by microwave irradiation using allenyl boron compounds in a chemo- and regioselective way is described. The corresponding products were obtained in short reaction time, high yield and purity without the need of any solvent when allenyl boronic acid pinacol ester was used, or using a minimal amount of acetone when potassium allenyl trifluoroborate was used.

Keywords: boron compounds; microwave; propargylation; regioselectivity; synthesis

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When a peer-reviewed version of this preprint is available in the Beilstein Journals, this information will be updated in the information box above. If no peer-reviewed version is available, please cite this preprint using the following information:

Freitas, J. J.; Freitas, Q. P.; Andrade, S. R.; Freitas, J. C.; Oliveira, R. A.; Menezes, P. H. Beilstein Arch. 2019, 2019138. doi:10.3762/bxiv.2019.138.v1

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© 2019 Freitas et al.; licensee Beilstein-Institut.
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