Microwave-assisted Synthesis of 2-Substituted 4,5,6,7-Tetrahydro-1,3-thiazepines from 4-Aminobutanol

  1. María C. Mollo,
  2. Natalia B. Kilimciler,
  3. Juan A. Bisceglia and
  4. Liliana R. OrelliORCID Logo

Submitting author affiliation: Facultad de Farmacia y Bioquimica-Universidad de Buenos Aires, Buenos Aires, Argentina

Beilstein Arch. 2019, 2019135. doi:10.3762/bxiv.2019.135.v1

Published 28 Oct 2019

  • Preprint

Abstract

A general procedure for the synthesis of 2-substituted tetrahydro-1,3-thiazepines is presented, by MW-assisted cyclization of 4-thioamidobutanols. The acyclic precursors were prepared in high overall yields by an expeditious three step diacylation/thionation/deprotection sequence from 4-aminobutanol. Microwave assisted ring closure of 4-thioamidoalcohols promoted by trimethylsilyl polyphosphate (PPSE) in solvent-free conditions allowed for the synthesis of several hitherto unreported seven-membered iminothioethers bearing 2-aryl, alkenyl, aralkyl and alkyl substituents. The cyclodehydration reaction is likely to involve a SN2-type displacement and affords good to excellent yields of the desired heterocycles in very short reaction times.

Keywords: medium-size heterocycles; tetrahydrothiazepines; cyclodehydration; microwaves; PPSE

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When a peer-reviewed version of this preprint is available in the Beilstein Journals, this information will be updated in the information box above. If no peer-reviewed version is available, please cite this preprint using the following information:

Mollo, M. C.; Kilimciler, N. B.; Bisceglia, J. A.; Orelli, L. R. Beilstein Arch. 2019, 2019135. doi:10.3762/bxiv.2019.135.v1

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