A green and efficient cyclocondensation reaction of β-ethylthio-β-indolyl-α, β-unsaturated ketones with semicarbazide hydrochloride as hydrazine equivalent to prepare 3-pyrazolyl indoles had been developed in the presence of 3 equiv. of PEG-400 in reflux water. This procedure did not require toxic hydrazine and product purification, eliminating the use of toxic liquid chemicals.
Keywords: 3-pyrazolyl indoles; semicarbazide hydrochloride; polyethylene glycols; aqueous synthesis; hydrazine equivalent.
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When a peer-reviewed version of this preprint is available in the Beilstein Journals, this information will be updated in the information box above. If no peer-reviewed version is available, please cite this preprint using the following information:
zhao, Y.; yu, H.; liao, P.; wang, W. Beilstein Arch. 2019, 2019118. doi:10.3762/bxiv.2019.118.v1
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