Green Cyclocondensation of β-Ethylthio-β-indolyl-α, β-unsaturated Ketones with Semicarbazide Hydrochloride as Hydrazine Equivalent in Water: Aqueous Synthesis of 3-Pyrazolyl Indoles

Submitting author affiliation:
Baicheng Normal University, Baicheng, baicheng, China

Beilstein Arch. 2019, 2019118.

Published 08 Oct 2019

cc-by Logo
This preprint has not been peer-reviewed. When a peer-reviewed version is available, this information will be updated.


A green and efficient cyclocondensation reaction of β-ethylthio-β-indolyl-α, β-unsaturated ketones with semicarbazide hydrochloride as hydrazine equivalent to prepare 3-pyrazolyl indoles had been developed in the presence of 3 equiv. of PEG-400 in reflux water. This procedure did not require toxic hydrazine and product purification, eliminating the use of toxic liquid chemicals.

Keywords: 3-pyrazolyl indoles; semicarbazide hydrochloride; polyethylene glycols; aqueous synthesis; hydrazine equivalent.

Supporting Information

Format: DOCX Size: 3.3 MB   Download

How to Cite

When a peer-reviewed version of this preprint is available, this information will be updated in the information box above. If no peer-reviewed version is available, please cite this preprint using the following information:

zhao, Y.; yu, H.; liao, P.; wang, W. Beilstein Arch. 2019, 2019118. doi:10.3762/bxiv.2019.118.v1

Download Citation

Citation data can be downloaded as file using the "Download" button or used for copy/paste from the text window below.
Citation data in RIS format can be imported by all major citation management software, including EndNote, ProCite, RefWorks, and Zotero.