Green Cyclocondensation of β-Ethylthio-β-indolyl-α, β-unsaturated Ketones with Semicarbazide Hydrochloride as Hydrazine Equivalent in Water: Aqueous Synthesis of 3-Pyrazolyl Indoles

  1. yanhui zhao,
  2. haifeng yuORCID Logo,
  3. peiqiu liao and
  4. wenju wang

Submitting author affiliation: Baicheng Normal University, Baicheng, baicheng, China

Beilstein Arch. 2019, 2019118. doi:10.3762/bxiv.2019.118.v1

Published 08 Oct 2019

  • Preprint


A green and efficient cyclocondensation reaction of β-ethylthio-β-indolyl-α, β-unsaturated ketones with semicarbazide hydrochloride as hydrazine equivalent to prepare 3-pyrazolyl indoles had been developed in the presence of 3 equiv. of PEG-400 in reflux water. This procedure did not require toxic hydrazine and product purification, eliminating the use of toxic liquid chemicals.

Keywords: 3-pyrazolyl indoles; semicarbazide hydrochloride; polyethylene glycols; aqueous synthesis; hydrazine equivalent.

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zhao, Y.; yu, H.; liao, P.; wang, W. Beilstein Arch. 2019, 2019118. doi:10.3762/bxiv.2019.118.v1

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