8-(Dichloromethylene)-3,4,7,8-tetrahydro-6H-imidazo[5,1-c][1,2,4,6]thiatriazin-6-one 2,2-dioxides: synthesis, structure and antiproliferative activity evaluation

Oleh V. Shablykin; Yurii Eu Kornii; Kateryna R. Bondarenko; Svitlana V. Shishkina; Andrii V. Kozytskyi; Olga V. Shablykina

doi:10.3762/bxiv.2026.7.v1

8-(Dichloromethylene)-3,4,7,8-tetrahydro-6H-imidazo[5,1-c][1,2,4,6]thiatriazin-6-one 2,2-dioxides: synthesis, structure and antiproliferative activity evaluation

Oleh V. Shablykin ,
Yurii Eu Kornii ,
Kateryna R. Bondarenko ,
Svitlana V. Shishkina ,
Andrii V. Kozytskyi and
Olga V. Shablykina

Submitting author affiliation:

V.P. Kukhar Institute of Bioorganic chemistry and Petrochemistry NAS of Ukraine, Ukraine; Enamine Ltd., Ukraine, Kyiv, Ukraine

Beilstein Arch. 2026, 20267. https://doi.org/10.3762/bxiv.2026.7.v1

Published 06 Feb 2026

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Show All Preprints Nanotechnology Organic chemistry Bioorganic chemistry / chemical biology Catalysis Chemical methods and reactions Flow and process chemistry Green and sustainable chemistry Materials chemistry Medicinal and pharmaceutical chemistry Nano- and molecular-scale electronics Nano-biomaterials and bioscience Nanomagnetics Nanomaterials, thin films and nanointerfaces Nanomedicine Nanometrology and nanomechanics Nano-optics Nanopatterning, self-assembly and nanofabrication Nanostructures for energy and sensing applications Natural products chemistry Organo main group chemistry Other nanotechnology (unclassified) Other organic chemistry (unclassified) Photochemistry and photovoltaics Physical organic chemistry Supramolecular chemistry

Abstract

Through cyclization of 4-(dichloromethylene)-5-(aminosulfonylimino)imidazolidin-2-ones by formaldehyde action series of 8-(dichloromethylene)-3,4,7,8-tetrahydro-6H-imidazo[5,1-c][1,2,4,6]thiatriazin-6-one 2,2-dioxides were synthesized. Their structure parameters were discovered by NMR experiments and X-Ray analysis. The separate products (with allyl, carbethoxymethyl, 2-N-Boc-aminoethyl, 2-(N-Boc-N-isopropoxymethylamino)ethyl substituents in position 3) demonstrated high antiproliferative activity

Keywords: 4-(dichloromethylene)-5-(aminosulfonylimino)imidazolidin-2-one; cyclization; aminal; imidazo[5,1-c][1,2,4,6]thiatriazine; antiproliferative activity

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Shablykin, O. V.; Kornii, Y. E.; Bondarenko, K. R.; Shishkina, S. V.; Kozytskyi, A. V.; Shablykina, O. V. Beilstein Arch. 2026, 20267. doi:10.3762/bxiv.2026.7.v1

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aromatic	the word “aromatic”
aromatic aldehyde	the word “aromatic” OR “aldehyde”
+aromatic +aldehyde	both words “aromatic” AND “aldehyde”
+aromatic -aldehyde	the word “aromatic” but NOT “aldehyde”
“aromatic aldehyde”	the exact phrase “aromatic aldehyde”
benz*	words which begin with “benz”, such as “benzene” or “benzyl”
benz*yl	words that begin with “benz” and end with “yl”, such as “benzyl” or “benzoyl”
benzyl~	words that are close to the word “benzyl”, such as “benzoyl” (i.e., fuzzy search)