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Beilstein Arch. 2026, 202623. https://doi.org/10.3762/bxiv.2026.23.v1
Published 07 Jul 2026
Study toward the undirected fluorination and chlorination of cubane 1,4-diester is described by C-H activation using friendly-user reagent such as Selectfluor and dichlorodimethyl hydantoin under photoinduction. While the fluorocubane 1,4-diester is formed in low yield (8 % yield) due to loss of material, the chlorocubane 1,4-diester was on the other hand prepared in good yield (59%, 76% conversion) without the need of photocatalyst. Moreover, the chlorination of the strained scaffold was developed using flow technology.
Keywords: fluorination; chlorination; cubane 1,4-diester; C-H activation; photoactivation
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Donnier-Valentin, L.; Heinrich, R.; Fevre-Renault, Q.; Legros, J.; Linclau, B.; DE PAOLIS, M. Beilstein Arch. 2026, 202623. doi:10.3762/bxiv.2026.23.v1
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