Beilstein Arch. 2025, 202563. https://doi.org/10.3762/bxiv.2025.63.v1
Published 19 Nov 2025
Stable and highly reactive 3-pyrazolyl oxindole derivatives have been developed as a novel three-carbon synthon, which undergo a formal [3+2] annulation with isatin promoted by non-nucleophilic base. This protocol provides a direct route for the rapid construction of a novel class of 3,3’-polyspiro oxindole-γ-butyrolactone scaffolds. These polyspiro frameworks are recognized as privileged scaffolds for a wide range of bioactive compounds. The developed protocol features mild reaction conditions, a broad substrate scope, and scalability.
Keywords: 3-Pyrazolyl oxindole; base-promoted; [3+2] annulation; polyspiro oxindole
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Jia, Y.; Mu, T.; Liu, H.; Xiang, M.; Shen, L. Beilstein Arch. 2025, 202563. doi:10.3762/bxiv.2025.63.v1
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