Beilstein Arch. 2025, 202548. https://doi.org/10.3762/bxiv.2025.48.v1
Published 24 Jul 2025
A one-pot Ugi-azide reaction followed by intramolecular Cu-free azide-alkyne cycloaddition generates a polycyclic scaffold 7 bearing polycyclic triazole, tetrazole and benzodiazepine rings. This method could be extended for making a more complicated scaffold 8 containing piperazinone ring.
Keywords: multicomponent reaction; one-pot, Ugi-azide reaction; polycyclic; benzodiazepine; triazole; tetrazole; piperazinone; click reaction
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Ma, X.; Gao, Z.; Niu, J.; Shao, W.; Yan, S.; Zhang, S.; Zhang, W. Beilstein Arch. 2025, 202548. doi:10.3762/bxiv.2025.48.v1
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