Transition Metal Free Decarbonyl-Oxidation of 3-Arylbenzofuran-2(3H)-ones: Access to 2-Hydroxy Benzophenones

Submitting author affiliation:
Bhabha Atomic Research Centre, Mumbai, India

Beilstein Arch. 2024, 202444.

Published 25 Jun 2024

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This preprint has not been peer-reviewed. When a peer-reviewed version is available, this information will be updated.


A transition metal-free decarbonyl-oxidation protocol for conversion of 3-Arylbenzofuran-2(3H)-ones to 2-hydroxybenzophenones under mild conditions has been developed. NMR studies confirmed the role of in-situ generated hydroperoxide in the conversion. The protocol was applied to a diverse range of substrates to access the target products in good to excellent yields. A structure-activity study for the 5-substituted-2-hydroxybenzophenones towards UV-protection abilities have been verified by mathematical calculations.

Keywords: 2-Hydroxy benzophenone; decarbonyl-oxidation; transition metal-free; hydroperoxide; UV-protection

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When a peer-reviewed version of this preprint is available, this information will be updated in the information box above. If no peer-reviewed version is available, please cite this preprint using the following information:

DHOTARE, B. B.; Kanojia, S. V.; Sakhiya, C. K.; Wadawale, A.; Goswami, D. Beilstein Arch. 2024, 202444. doi:10.3762/bxiv.2024.44.v1

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