One-pot Ugi-azide and Heck reactions for the synthesis of heterocyclic systems containing tetrazole and 1,2,3,4-tetrahydroisoquinoline

Submitting author affiliation:
University of Massachusetts Boston, Boston, United States

Beilstein Arch. 2024, 20242.

Published 18 Jan 2024

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A new method for the synthesis of heterocyclic systems containing tetrazole and tetrahydroisoquinoline is developed via the performance of one-pot Ugi-azide and Heck cyclization reactions. The integration of the multicomponent and post-condensation reactions in one-pot maximizes the pot-, atom-, and step-economy (PASE).

Keywords: Ugi-azide reaction; Heck reaction; one-pot; tetrazole; tetrahydroisoquinoline; tetrazolo-pyrazino[2,1-a]isoquinolin-6(5H)-ones

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Niu, J.; Wang, Y.; Yan, S.; Zhang, Y.; Ma, X.; Zhang, Q.; Zhang, W. Beilstein Arch. 2024, 20242. doi:10.3762/bxiv.2024.2.v1

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