Bismuth(III) Triflate: An Economical and Environmentally Friendly Catalyst for the Nazarov Reaction

Submitting author affiliation:
University of Campinas, Campinas, Brazil

Beilstein Arch. 2024, 20241.

Published 03 Jan 2024

cc-by Logo


We describe the use of bismuth (III) triflate as an efficient and environmentally friendly catalyst for the Nazarov reaction of aryl vinyl ketones, leading to the synthesis of 3-aryl-2-carboethoxy-1-indanones and 3-aryl-1-indanones. By changing the temperature and reaction time, it was possible to modulate the reactivity, allowing the synthesis of two different products in good to excellent yields (3-aryl-2-carboethoxy-1-indanones and 3-aryl-2-carbethoxy-1-indanones). The reaction does not need additives and is insensitive to both air and moisture. The preliminary biological evaluation of some indanones show a promissory profile against some human cancer line cells.

Keywords: Indanones; Heterocycles; Nazarov reaction; Bismuth; Catalysis

Supporting Information

Format: PDF Size: 7.2 MB   Download

How to Cite

When a peer-reviewed version of this preprint is available, this information will be updated in the information box above. If no peer-reviewed version is available, please cite this preprint using the following information:

Rodrigues Jr., M. T.; de Oliveira, A. S. B.; Gomes, R. D. C.; Hirata, A. S.; Zeoly, L. A.; Santos, H.; Arantes, J.; Reis-Silva, C. S. M.; Machado-Neto, J. A.; Costa-Lotufo, L. V.; Coelho, F. Beilstein Arch. 2024, 20241. doi:10.3762/bxiv.2024.1.v1

Download Citation

Citation data can be downloaded as file using the "Download" button or used for copy/paste from the text window below.
Citation data in RIS format can be imported by all major citation management software, including EndNote, ProCite, RefWorks, and Zotero.