Bismuth(III) Triflate: An Economical and Environmentally Friendly Catalyst for the Nazarov Reaction

Submitting author affiliation:
University of Campinas, Campinas, Brazil

Beilstein Arch. 2024, 20241.

Published 03 Jan 2024

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This preprint has not been peer-reviewed. When a peer-reviewed version is available, this information will be updated.


We describe the use of bismuth (III) triflate as an efficient and environmentally friendly catalyst for the Nazarov reaction of aryl vinyl ketones, leading to the synthesis of 3-aryl-2-carboethoxy-1-indanones and 3-aryl-1-indanones. By changing the temperature and reaction time, it was possible to modulate the reactivity, allowing the synthesis of two different products in good to excellent yields (3-aryl-2-carboethoxy-1-indanones and 3-aryl-2-carbethoxy-1-indanones). The reaction does not need additives and is insensitive to both air and moisture. The preliminary biological evaluation of some indanones show a promissory profile against some human cancer line cells.

Keywords: Indanones; Heterocycles; Nazarov reaction; Bismuth; Catalysis

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When a peer-reviewed version of this preprint is available, this information will be updated in the information box above. If no peer-reviewed version is available, please cite this preprint using the following information:

Rodrigues Jr., M. T.; de Oliveira, A. S. B.; Gomes, R. D. C.; Hirata, A. S.; Zeoly, L. A.; Santos, H.; Arantes, J.; Reis-Silva, C. S. M.; Machado-Neto, J. A.; Costa-Lotufo, L. V.; Coelho, F. Beilstein Arch. 2024, 20241. doi:10.3762/bxiv.2024.1.v1

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