Synthesis of aliphatic nitriles from cyclobutanone oxime mediated by sulfuryl fluoride (SO2F2)

Submitting author affiliation:
Wuhan University of Technology, Wuhan, China

Beilstein Arch. 2023, 20239.

Published 03 Apr 2023

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A SO2F2-mediated ring-opening cross-coupling of cyclobutanone oxime derivatives with alkenes was developed for the construction of a range of δ-olefin-containing aliphatic nitriles with (E)-configuration-selectivity. This new method feathers wide substrate scope, mild condition and direct N−O activation.

Keywords: Direct N−O activation; (E)-configuration-selectivity; Nitriles synthesis; Ring-opening cross-coupling; Sulfuryl fluoride (SO2F2)

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Chen, X.-L.; Qin, H.-L. Beilstein Arch. 2023, 20239. doi:10.3762/bxiv.2023.9.v1

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