Potential of deep eutectic solvents in silver nanoparticles fabrication for antibiotic residue detection

Submitting author affiliation:
University of Science, Vietnam National University, Ho Chi Minh City (VNUHCM), Ho Chi Minh, Viet Nam

Beilstein Arch. 2023, 202365. https://doi.org/10.3762/bxiv.2023.65.v1

Published 27 Dec 2023

cc-by Logo


Deep eutectic solvents (DESs) have been well-known lately because of their exceptional thermal stability, polarity, and environmental friendliness. There have been numerous advancements in silver nanoparticles (Ag NPs) fabrication, but no attention to the potential of DES in Ag NPs synthesis is considered and studied carefully. In this study, we present a novel strategy using a selected DES to fabricate Ag NPs in which AgNO3 is chemically reduced by L-ascorbic acid. The results adapted from characterization methods demonstrate that Ag NPs are successfully fabricated, which are further used for the construction of the surface-enhanced Raman scattering (SERS) substrate. The two analytes chosen for SERS quantitation are nitrofurantoin (NFT) and sulfadiazine (SDZ), which throughout the SERS technology, their residues can be traced at 10-8 M for both NFT and SDZ. The highest enhancement factors (EFs) are competitive, 6.29Ï107 and 1.69Ï107 for NFT and SDZ, respectively. Besides, the linearity coefficients are extremely close to 1 in the range of 10-8 M to 10-3 M of concentration, and the SERS substrate shows attentional uniformity along with great selectivity. These powerful SERS performances coherently indicate that DESs have tremendous potential in nanomaterials fabrication applied for biosensors’ substrate construction.

Keywords: Ag NPs, deep eutectic solvents, potential, antibiotic residue, SERS

How to Cite

When a peer-reviewed version of this preprint is available, this information will be updated in the information box above. If no peer-reviewed version is available, please cite this preprint using the following information:

Tho, L. H.; Khuyen, B. X.; Mai, N. X. D.; Tran, N. H. T. Beilstein Arch. 2023, 202365. doi:10.3762/bxiv.2023.65.v1

Download Citation

Citation data can be downloaded as file using the "Download" button or used for copy/paste from the text window below.
Citation data in RIS format can be imported by all major citation management software, including EndNote, ProCite, RefWorks, and Zotero.