Undescribed triterpenoids obtained from Dictamnus dasycarpus Turcz and their anti-proliferation activities

Submitting author affiliation:
Heilongjiang University of Chinese medicine, harbin, China

Beilstein Arch. 2023, 202347. https://doi.org/10.3762/bxiv.2023.47.v1

Published 01 Nov 2023

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This preprint has not been peer-reviewed. When a peer-reviewed version is available, this information will be updated.


Three new triterpenoids, named dictamtriterpenol B-D (1-3), along with ten known compounds (4-13), were isolated from Dictamnus dasycarpus Turcz. The structures of all compounds were characterized by spectroscopic methods, including IR, HR-ESI-MS, 1D and 2D NMR. Furthermore, HepG2 and A549 cell lines were used to evaluate their anti-proliferation activities. And compounds 1, 5, and 8 (IC50 values in the range of 1.84±0.03 to 14.98±0.39 μM) displayed significant anti-proliferation activity against HepG2 cells. As well as compounds 1, 4, 9, 10, and 13 (IC50 values in the range of 1.63±0.04 to 8.56±1.46 μM) displayed significant anti-proliferation activity against A549 cells.

Keywords: Dictamnus dasycarpus Turcz; Triterpenoids; Anti-proliferation

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When a peer-reviewed version of this preprint is available, this information will be updated in the information box above. If no peer-reviewed version is available, please cite this preprint using the following information:

sun, Y.; liu, Y.; wang, S.; yang, X.; wu, J.; pan, J.; hao, Z.; guan, W.; xu, Z.; zhou, Y.; lv, S.; kuang, H.; yang, B. Beilstein Arch. 2023, 202347. doi:10.3762/bxiv.2023.47.v1

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