Beilstein Arch. 2023, 202341. https://doi.org/10.3762/bxiv.2023.41.v1
Published 05 Oct 2023
A technique has been proposed for incorporating a heterocyclic component into a glutarimide framework employing Rh2(esp)2-catalysed N-H insertion with the involvement of N-Boc-α-diazo glutarimide. The new diazo reagent is more stable, soluble and convenient to prepare than the previously suggested one. The approach permits the application of diverse heterocycles, including both aromatic and saturated NH-substrates. This yields structures that are appealing for generating Cereblon ubiquitin-ligase ligands and for potential use in crafting PROTAC molecules.
Keywords: diazocarbonyl compounds, Rh(II)-catalysis, NH insertion reaction, N-heterocycles, CRBN ligands
| Format: PDF | Size: 5.6 MB | Download |
When a peer-reviewed version of this preprint is available, this information will be updated in the information box above. If no peer-reviewed version is available, please cite this preprint using the following information:
Kantin, G.; Golubev, P.; Sapegin, A.; Bunev, A.; Dar'in, D. Beilstein Arch. 2023, 202341. doi:10.3762/bxiv.2023.41.v1
Citation data can be downloaded as file using the "Download" button or used for copy/paste from the text window below.
Citation data in RIS format can be imported by all major citation management software, including EndNote, ProCite, RefWorks, and
Zotero.
© 2023 Kantin et al.; licensee Beilstein-Institut.
This is an open access work licensed under the terms of the Beilstein-Institut Open Access License Agreement (https://www.beilstein-archives.org/xiv/terms), which is identical to the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0). The reuse of material under this license requires that the author(s), source and license are credited. Third-party material in this work could be subject to other licenses (typically indicated in the credit line), and in this case, users are required to obtain permission from the license holder to reuse the material.
