Curcumin-loaded albumin submicron particles with its potential as a cancer therapy: an in vitro study

Submitting author affiliation:
University of Phayao, Phayao, Thailand

Beilstein Arch. 2023, 202331.

Published 25 Jul 2023

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Curcumin (CUR), a polyphenolic compound, shows promising biological properties, particularly antioxidant activity. However, its medical applications are limited due to its low water solubility, bioavailability, and pH-instability. CUR-loaded albumin microparticles (CUR-HSA-MPs) of submicron size in the range of 800 to 900 nm and a zeta-potential of -15 mV were prepared. The CUR loading efficiency was up to 65%. A maximum release of 36% of the encapsulated CUR in 50% ethanol in PBS, pH 7, was observed within 6 h, demonstrating sustainable release. The in vitro cytotoxicity of CUR-HSA-MPs showed promising anticancer potential against human hepatocellular carcinoma (Huh-7) and human breast adenocarcinoma (MCF-7) cell lines, although this effect was less pronounced in human dermal fibroblasts (HDFB) and human cholangiocyte (MMN) cell lines. Confocal microscopy was used to confirm the uptake of CUR-HSA-MPs by cancer cells. Our studies revealed that HSA-MPs are potentially promising vehicles for increasing the solubility and bioavailability of CUR.

Keywords: curcumin; albumin submicron particles; cancer therapy; drug delivery

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Suwannasom, N.; Sriaksorn, N.; Thepmalee, C.; Khoothiam, K.; Prapan, A.; Bäumler, H.; Thephinlap, C. Beilstein Arch. 2023, 202331. doi:10.3762/bxiv.2023.31.v1

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