,
,
,
,
,
and
Beilstein Arch. 2023, 202331. https://doi.org/10.3762/bxiv.2023.31.v1
Published 25 Jul 2023
Curcumin (CUR), a polyphenolic compound, shows promising biological properties, particularly antioxidant activity. However, its medical applications are limited due to its low water solubility, bioavailability, and pH-instability. CUR-loaded albumin microparticles (CUR-HSA-MPs) of submicron size in the range of 800 to 900 nm and a zeta-potential of -15 mV were prepared. The CUR loading efficiency was up to 65%. A maximum release of 36% of the encapsulated CUR in 50% ethanol in PBS, pH 7, was observed within 6 h, demonstrating sustainable release. The in vitro cytotoxicity of CUR-HSA-MPs showed promising anticancer potential against human hepatocellular carcinoma (Huh-7) and human breast adenocarcinoma (MCF-7) cell lines, although this effect was less pronounced in human dermal fibroblasts (HDFB) and human cholangiocyte (MMN) cell lines. Confocal microscopy was used to confirm the uptake of CUR-HSA-MPs by cancer cells. Our studies revealed that HSA-MPs are potentially promising vehicles for increasing the solubility and bioavailability of CUR.
Keywords: curcumin; albumin submicron particles; cancer therapy; drug delivery
| Format: DOCX | Size: 1.3 MB | Download |
When a peer-reviewed version of this preprint is available, this information will be updated in the information box above. If no peer-reviewed version is available, please cite this preprint using the following information:
Suwannasom, N.; Sriaksorn, N.; Thepmalee, C.; Khoothiam, K.; Prapan, A.; Bäumler, H.; Thephinlap, C. Beilstein Arch. 2023, 202331. doi:10.3762/bxiv.2023.31.v1
Citation data can be downloaded as file using the "Download" button or used for copy/paste from the text window below.
Citation data in RIS format can be imported by all major citation management software, including EndNote, ProCite, RefWorks, and
Zotero.
© 2023 Suwannasom et al.; licensee Beilstein-Institut.
This is an open access work licensed under the terms of the Beilstein-Institut Open Access License Agreement (https://www.beilstein-archives.org/xiv/terms), which is identical to the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0). The reuse of material under this license requires that the author(s), source and license are credited. Third-party material in this work could be subject to other licenses (typically indicated in the credit line), and in this case, users are required to obtain permission from the license holder to reuse the material.
