Green SPIONs as a novel highly selective treatment for leishmaniasis: an in vitro study against Leishmania amazonensis intracellular amastigotes

Submitting author affiliation:
Universidade Federal do Rio de Janeiro, Duque de Caxias, Brazil

Beilstein Arch. 2023, 202317.

Published 24 Apr 2023

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Objective: The main goal of this work was to evaluate the therapeutic potential of green SPIONs produced with coconut water for treating cutaneous leishmaniasis caused by Leishmania amazonensis. Materials and methods: Optical and electron microscopy techniques were used to evaluate the effects on cell proliferation, infectivity percentage, and ultrastructure. Results: SPIONs were internalized by both parasite stages, randomly distributed by the cytosol located mainly in membrane-bound compartments. The selectivity index for intracellular amastigotes was higher than 240 times compared to current drugs used to treat the disease. Conclusion: The synthesized SPIONs showed an important and promising anti-Leishmania activity and can be considered a strong candidate for a new therapeutic approach for treating leishmaniases.

Keywords: Leishmaniasis; SPIONs; Leishmania amazonensis; nanomedicine; coconut water.

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Verçoza, B. R. F.; Bernardo, R. R.; de Oliveira, L. A. S.; Rodrigues, J. C. F. Beilstein Arch. 2023, 202317. doi:10.3762/bxiv.2023.17.v1

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