Beilstein Arch. 2023, 202310. https://doi.org/10.3762/bxiv.2023.10.v1
Published 04 Apr 2023
Quinoline based sulfonyl derivatives, and especially sulfonamides, are relevant and promising structures for drug design. We have developed a new convenient protocol for the synthesis of 3-sulfonyl substituted quinolines (sulfonamides and sulfones). The approach is based on Knoevenagel condensation/aza-Wittig reaction cascade involving o-azidobenzaldehydes and ketosulfonamides or ketosulfones as key building blocks. The protocol is appropriate both for ketosulfonyl reagents and α-sulfonyl alkyl acetates providing the target quinoline derivatives in good to excellent yields.
Keywords: quinolines, sulfonamides, cyclocondensation, aza-Wittig reaction, azides
|Format: PDF||Size: 3.2 MB||Download|
When a peer-reviewed version of this preprint is available, this information will be updated in the information box above. If no peer-reviewed version is available, please cite this preprint using the following information:
Malkova, K.; Bubyrev, A.; Kalinin, S.; Dar'in, D. Beilstein Arch. 2023, 202310. doi:10.3762/bxiv.2023.10.v1
Citation data can be downloaded as file using the "Download" button or used for copy/paste from the text window below.
Citation data in RIS format can be imported by all major citation management software, including EndNote, ProCite, RefWorks, and Zotero.
© 2023 Malkova et al.; licensee Beilstein-Institut.
This is an open access work licensed under the terms of the Beilstein-Institut Open Access License Agreement (https://www.beilstein-archives.org/xiv/terms), which is identical to the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0). The reuse of material under this license requires that the author(s), source and license are credited. Third-party material in this work could be subject to other licenses (typically indicated in the credit line), and in this case, users are required to obtain permission from the license holder to reuse the material.