,
,
and
Beilstein Arch. 2022, 202292. https://doi.org/10.3762/bxiv.2022.92.v1
Published 28 Dec 2022
An operationally simple, metal-free approach has been described for the synthesis of pyrazole tethered thioamide and amide conjugates. The thioamides were generated by employing a three-component reaction of diverse pyrazole C-3/4/5 carbaldehydes, secondary amines, and elemental sulfur in a single synthetic operation. The advantages of this developed protocol refer to the broad substrate scope, metal-free and easy to perform reaction conditions. Moreover, the pyrazole C-3/5 linked amide conjugates were also synthesized via oxidative amination of pyrazole carbaldehydes and 2-aminopyridines using hydrogen peroxide as an oxidant.
Keywords: Pyrazole carbaldehydes; Metal-free; C-S/O Bond Formation; Oxidative amidation;Thioamides
| Format: DOCX | Size: 4.3 MB | Download |
When a peer-reviewed version of this preprint is available, this information will be updated in the information box above. If no peer-reviewed version is available, please cite this preprint using the following information:
Sharma, S.; Singh, D.; Kumar, S.; , V.; Jamra, R.; Banyal, N.; , D.; Malakar, C. C.; Singh, V. Beilstein Arch. 2022, 202292. doi:10.3762/bxiv.2022.92.v1
Citation data can be downloaded as file using the "Download" button or used for copy/paste from the text window below.
Citation data in RIS format can be imported by all major citation management software, including EndNote, ProCite, RefWorks, and
Zotero.
© 2022 Sharma et al.; licensee Beilstein-Institut.
This is an open access work licensed under the terms of the Beilstein-Institut Open Access License Agreement (https://www.beilstein-archives.org/xiv/terms), which is identical to the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0). The reuse of material under this license requires that the author(s), source and license are credited. Third-party material in this work could be subject to other licenses (typically indicated in the credit line), and in this case, users are required to obtain permission from the license holder to reuse the material.
