An Efficient Metal-free and Catalyst-free C-S/C-O Bond Formation Strategy: Synthesis of Pyrazole Conjugated Thioamides and Amides

Submitting author affiliation:
Central University of Punjab, Bathinda, Bathinda, India

Beilstein Arch. 2022, 202292. https://doi.org/10.3762/bxiv.2022.92.v1

Published 28 Dec 2022

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Abstract

An operationally simple, metal-free approach has been described for the synthesis of pyrazole tethered thioamide and amide conjugates. The thioamides were generated by employing a three-component reaction of diverse pyrazole C-3/4/5 carbaldehydes, secondary amines, and elemental sulfur in a single synthetic operation. The advantages of this developed protocol refer to the broad substrate scope, metal-free and easy to perform reaction conditions. Moreover, the pyrazole C-3/5 linked amide conjugates were also synthesized via oxidative amination of pyrazole carbaldehydes and 2-aminopyridines using hydrogen peroxide as an oxidant.

Keywords: Pyrazole carbaldehydes; Metal-free; C-S/O Bond Formation; Oxidative amidation;Thioamides

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Sharma, S.; Singh, D.; Kumar, S.;  , V.; Jamra, R.; Banyal, N.;  , D.; Malakar, C. C.; Singh, V. Beilstein Arch. 2022, 202292. doi:10.3762/bxiv.2022.92.v1

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