Design and Synthesis of Pyrene Containing Unusual α-Amino Acid Derivatives

Submitting author affiliation:
Indian Institute of Technology-Bombay, Powai, Mumbai, Mumbai, India

Beilstein Arch. 2022, 202281.

Published 06 Oct 2022

cc-by Logo
This preprint has not been peer-reviewed. When a peer-reviewed version is available, this information will be updated.


We report here, constrained α-amino acid derivatives containing pyrene ring by using ethyl isocyanoacetate as a glycine equivalent. The required starting precursor 1,4,5,8-tetrakis(bromomethyl)naphthalene 14 was prepared starting with commercially available naphthalene-1,4,5,8-tetracarboxylic anhydride 15 in a three step sequence.

Keywords: Esterification, reduction, ethyl isocyanoacetate, hydrolysis, N-acylation, amino acid.  

Supporting Information

Format: PDF Size: 5.0 MB   Download

How to Cite

When a peer-reviewed version of this preprint is available, this information will be updated in the information box above. If no peer-reviewed version is available, please cite this preprint using the following information:

Kotha, S.; Gaikwad, V.; Ansari, S. Beilstein Arch. 2022, 202281. doi:10.3762/bxiv.2022.81.v1

Download Citation

Citation data can be downloaded as file using the "Download" button or used for copy/paste from the text window below.
Citation data in RIS format can be imported by all major citation management software, including EndNote, ProCite, RefWorks, and Zotero.