Design and Synthesis of Pyrene Containing Unusual α-Amino Acid Derivatives

Submitting author affiliation:
Indian Institute of Technology-Bombay, Powai, Mumbai, Mumbai, India

Beilstein Arch. 2022, 202281.

Published 06 Oct 2022

This preprint has not been peer-reviewed. When a peer-reviewed version is available, this information will be updated.


We report here, constrained α-amino acid derivatives containing pyrene ring by using ethyl isocyanoacetate as a glycine equivalent. The required starting precursor 1,4,5,8-tetrakis(bromomethyl)naphthalene 14 was prepared starting with commercially available naphthalene-1,4,5,8-tetracarboxylic anhydride 15 in a three step sequence.

Keywords: Esterification, reduction, ethyl isocyanoacetate, hydrolysis, N-acylation, amino acid.  

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When a peer-reviewed version of this preprint is available, this information will be updated in the information box above. If no peer-reviewed version is available, please cite this preprint using the following information:

Kotha, S.; Gaikwad, V.; Ansari, S. Beilstein Arch. 2022, 202281. doi:10.3762/bxiv.2022.81.v1

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