Beilstein Arch. 2022, 202281. https://doi.org/10.3762/bxiv.2022.81.v1
Published 06 Oct 2022
We report here, constrained α-amino acid derivatives containing pyrene ring by using ethyl isocyanoacetate as a glycine equivalent. The required starting precursor 1,4,5,8-tetrakis(bromomethyl)naphthalene 14 was prepared starting with commercially available naphthalene-1,4,5,8-tetracarboxylic anhydride 15 in a three step sequence.
Keywords: Esterification, reduction, ethyl isocyanoacetate, hydrolysis, N-acylation, amino acid.
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Kotha, S.; Gaikwad, V.; Ansari, S. Beilstein Arch. 2022, 202281. doi:10.3762/bxiv.2022.81.v1
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