Novel Bis-Triazole Scaffold Accessed via Two Tandem [3+2] Cycloaddition Events Including an Uncatalyzed, Room-Temperature Azide-Alkyne Click Reaction

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Saint Petersburg State University, Peterhof, Russian Federation

Beilstein Arch. 2022, 202280.

Published 30 Sep 2022



The previously described α-acetyl-α-diazomethane sulfonamide was employed in a three-component reaction with azide-containing benzaldehydes and propargylamines. Besides the initial formation of the triazole core, the reaction proceeded further, in uncatalyzed fashion at room temperature and yielded, after intramolecular azide-alkyne click reaction novel, structurally intriguing bis-triazoles.

Keywords: 1,2,3-Triazoles; α-acetyl-α-diazomethane sulfonamide; intramolecular click reaction; uncatalyzed; room temperature

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Malkova, K.; Bubyrev, A.; Krivovicheva, V.; Dar'in, D.; Bunev, A.; Krasavin, M. Beilstein Arch. 2022, 202280. doi:10.3762/bxiv.2022.80.v1

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