A one-pot multicomponent K-10 clay catalyzed synthesis of 2-Amino-3,5-dicarbonitrile-6-thiopyridines

Submitting author affiliation:
The IIS University, Jaipur, India

Beilstein Arch. 2022, 202273. https://doi.org/10.3762/bxiv.2022.73.v1

Published 19 Sep 2022

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Abstract

2-Amino-3,5-dicarbonitrile-6-thiopyridines occupy a prominent place among the physiologically and biologically active scaffolds owing to their therapeutic applications in the treatment of Parkinson’s disease, asthma, urinary incontinence, kidney disease, the Hepatitis B Foundation infections, Creutzfeldt–Jacob disease, cancer, hypoxia/ischemia and epilepsy. A one-pot, multicomponent condensation of aldehydes, malononitrile and thiophenol catalyzed by Montmorillonite K-10 clay afforded 2-amino-3,5-dicarbonitrile-6-thiopyridines in good to excellent yields. All the products could be well characterized on the basis of spectral studies. The catalyst could be recycled three times without affecting the yields and even in the fourth recycling of the catalyst, the yield decreases marginally. This approach manifests environmentally benign feasibility in contexts of enhanced yields, milder conditions, short reaction times and reusability of the catalyst.

Keywords: Multicomponent reaction; Montmorillonite K-10 clay catalysis; 2-Amino-3,5-dicarbonitrile-6-thiopyridines; Catalyst recycling; Green chemistry

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Sharma, P.; Sinha, P.; Bansal, R. K. Beilstein Arch. 2022, 202273. doi:10.3762/bxiv.2022.73.v1

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