Base-Catalyzed Diastereoselective Construction of Spiro-epoxyoxindoles  by the Darzens Reaction of 3-Chlorooxindoles with Aryl Aldehydes under Solvent-free Grinding

  1. Yue Li,
  2. Feng Wang,
  3. Li Liu,
  4. Rui Ning,
  5. Dulin Kong and
  6. Mingshu WuORCID Logo

Submitting author affiliation: Department of Chemistry, Hainan Normal University, Haikou, China

Beilstein Arch. 2022, 202244. https://doi.org/10.3762/bxiv.2022.44.v1

Published 07 Jun 2022

  • Preprint

Abstract

 A highly efficient, diastereoselective strategy for the synthesis of aryl-substituted spiro- epoxyoxindole derivatives by a Darzens-type reaction of α-chlorooxindoles with aryl aldehydes in the presence of bases under solvent-free grinding conditions has been developed. The process features with easy work-up, mild reaction condition, high to excellent diastereoselectivitie and yields as well as environmental compatibility.

Keywords: spiro-epoxyoxindoles; α-chlorooxindoles; Darzens-type reaction aldehydes; grinding; solvent-free

Supporting Information

Format: PDF Size: 6.4 MB   Download

How to Cite

When a peer-reviewed version of this preprint is available, this information will be updated in the information box above. If no peer-reviewed version is available, please cite this preprint using the following information:

Li, Y.; Wang, F.; Liu, L.; Ning, R.; Kong, D.; Wu, M. Beilstein Arch. 2022, 202244. doi:10.3762/bxiv.2022.44.v1

Download Citation
Download RIS (Reference Manager) Download BIB (BIBTEX)

© 2022 Li et al.; licensee Beilstein-Institut.
This is an open access work licensed under the terms of the Beilstein-Institut Open Access License Agreement (https://www.beilstein-archives.org/xiv/terms), which is identical to the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0). The reuse of material under this license requires that the author(s), source and license are credited. Third-party material in this work could be subject to other licenses (typically indicated in the credit line), and in this case, users are required to obtain permission from the license holder to reuse the material.

Other Beilstein-Institut Open Science Activities

Logo
Logo
Logo
Symposia