Base-Catalyzed Diastereoselective Construction of Spiro-epoxyoxindoles  by the Darzens Reaction of 3-Chlorooxindoles with Aryl Aldehydes under Solvent-free Grinding

Submitting author affiliation:
Department of Chemistry, Hainan Normal University, Haikou, China

Beilstein Arch. 2022, 202244.

Published 07 Jun 2022

This preprint has not been peer-reviewed. When a peer-reviewed version is available, this information will be updated.


 A highly efficient, diastereoselective strategy for the synthesis of aryl-substituted spiro- epoxyoxindole derivatives by a Darzens-type reaction of α-chlorooxindoles with aryl aldehydes in the presence of bases under solvent-free grinding conditions has been developed. The process features with easy work-up, mild reaction condition, high to excellent diastereoselectivitie and yields as well as environmental compatibility.

Keywords: spiro-epoxyoxindoles; α-chlorooxindoles; Darzens-type reaction aldehydes; grinding; solvent-free

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When a peer-reviewed version of this preprint is available, this information will be updated in the information box above. If no peer-reviewed version is available, please cite this preprint using the following information:

Li, Y.; Wang, F.; Liu, L.; Ning, R.; Kong, D.; Wu, M. Beilstein Arch. 2022, 202244. doi:10.3762/bxiv.2022.44.v1

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