A highly efficient, diastereoselective strategy for the synthesis of aryl-substituted spiro- epoxyoxindole derivatives by a Darzens-type reaction of α-chlorooxindoles with aryl aldehydes in the presence of bases under solvent-free grinding conditions has been developed. The process features with easy work-up, mild reaction condition, high to excellent diastereoselectivitie and yields as well as environmental compatibility.
Keywords: spiro-epoxyoxindoles; α-chlorooxindoles; Darzens-type reaction aldehydes; grinding; solvent-free
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Li, Y.; Wang, F.; Liu, L.; Ning, R.; Kong, D.; Wu, M. Beilstein Arch. 2022, 202244. doi:10.3762/bxiv.2022.44.v1
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