Electroreductive coupling of 2-acylbenzoates with α,β-unsaturated carbonyl compounds: density functional theory study on product selectivity

Submitting author affiliation:
Tottori University, Tottori, Japan

Beilstein Arch. 2022, 202238. https://doi.org/10.3762/bxiv.2022.38.v1

Published 27 May 2022



The electroreductive coupling of 2-acylbenzoates with acrylonitrile in the presence of TMSCl and successive treatment with 1 M HCl gave 2-cyanonaphthalen-1-ols or 3-(3-cyanoethyl)phthalides.  On the other hand, the reaction of 2-acylbenzoates with methyl vinyl ketone under the same conditions produced 3-(3-oxobutyl)phthalides as the sole products.  What determines the product selectivity was studied using the DFT calculations.

Keywords: 2-acylbenzoates; chlorotrimethylsilane; 3-(3-cyanoethyl)phthalides, 2-cyanonaphthalen-1-ols; electroductive coupling

Supporting Information

Format: PDF Size: 4.9 MB   Download
Format: CIF Size: 12.4 KB   Download

How to Cite

When a peer-reviewed version of this preprint is available, this information will be updated in the information box above. If no peer-reviewed version is available, please cite this preprint using the following information:

Kise, N.; Sakurai, T. Beilstein Arch. 2022, 202238. doi:10.3762/bxiv.2022.38.v1

Download citation
Download RIS (Reference Manager) Download BIB (BIBTEX)

© 2022 Kise and Sakurai; licensee Beilstein-Institut.
This is an open access work licensed under the terms of the Beilstein-Institut Open Access License Agreement (https://www.beilstein-archives.org/xiv/terms), which is identical to the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0). The reuse of material under this license requires that the author(s), source and license are credited. Third-party material in this work could be subject to other licenses (typically indicated in the credit line), and in this case, users are required to obtain permission from the license holder to reuse the material.