Copper–Catalyzed Multicomponent Reactions for Efficient Synthesis of Diverse Spirotetrahydrocarbazoles

Submitting author affiliation:
Yangzhou University, Yangzhou, China

Beilstein Arch. 2022, 202235.

Published 12 May 2022

cc-by Logo


In the presence of copper sulfate, the three or four-component reactions of 2-methylindole, aromatic aldehydes and various cyclic dienophiles in refluxing toluene afforded diverse spirotetrahydrocarbazoles. This reaction is a important development of Levy reaction by using 2-methylindole to replacing ethyl indole-2-acetate and successfully provided facile access to important polysubstituted spiro[carbazole-3,3'-indolines], spiro[carbazole-2,3'-indolines], spiro[carbazole-3,5'-pyrimidines] and spiro[carbazole-3,1'-cycloalkanes] in satisfactory yields and with high diastereoselectivity.

Keywords: Tetrahydrocarbazole; indole;  spirooxindole; indolo-2,3-quinodimethane; Diels-Alder reaction;  Levy reaction. .

Supporting Information

Format: PDF Size: 8.9 MB   Download

How to Cite

When a peer-reviewed version of this preprint is available, this information will be updated in the information box above. If no peer-reviewed version is available, please cite this preprint using the following information:

Zhan, S.-C.; Fang, R.-J.; Sun, J.; Yan, C.-G. Beilstein Arch. 2022, 202235. doi:10.3762/bxiv.2022.35.v1

Download Citation

Citation data can be downloaded as file using the "Download" button or used for copy/paste from the text window below.
Citation data in RIS format can be imported by all major citation management software, including EndNote, ProCite, RefWorks, and Zotero.