A Trustworthy Mechanochemical Route to Isocyanides: The Handyman of Chemistry

  1. Francesco Basoccu,
  2. Federico Cuccu,
  3. Federico Casti,
  4. Rita MocciORCID Logo,
  5. Claudia FattuoniORCID Logo and
  6. Andrea PorchedduORCID Logo

Submitting author affiliation: University of Cagliari, Monserrato, Italy

Beilstein Arch. 2022, 202221. https://doi.org/10.3762/bxiv.2022.21.v1

Published 05 Apr 2022

  • Preprint

Abstract

Isocyanides are hardly-to-produce, dramatically sensitive to purification processes and complex to handle as synthetic tools. Notwithstanding this, they represent one of the most refined and valuable compounds for accessing sophisticated and elegant synthetic routes. A unique interest has always been addressed to their production, though their synthetic pathways usually involve employing strong conditions and toxic reagents. The current paper intends to provide a conceptually innovative synthetic protocol designed for mechanochemical isocyanide preparation, simultaneously lowering the related reagents' toxicity and improving their purification in a straightforward procedure.

Keywords: mechanochemistry; isocyanide; isonitriles; green chemistry

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When a peer-reviewed version of this preprint is available, this information will be updated in the information box above. If no peer-reviewed version is available, please cite this preprint using the following information:

Basoccu, F.; Cuccu, F.; Casti, F.; Mocci, R.; Fattuoni, C.; Porcheddu, A. Beilstein Arch. 2022, 202221. doi:10.3762/bxiv.2022.21.v1

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© 2022 Basoccu et al.; licensee Beilstein-Institut.
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