Beilstein Arch. 2022, 202217. https://doi.org/10.3762/bxiv.2022.17.v1
Published 21 Mar 2022
Formation of unusual unsymmetrical dimers or/and indenes via Rh2(esp)2-catalyzed decomposition of diazo arylidene succinimides has been investigated. The reaction proceeded under mild conditions, and its result was shown to strongly depend on the nature of the substituents in the diazo substrate. The new reaction provides access to dibenzoazulenodipyrrole and indenopyrrole derivatives in moderate to high yield. Dibenzoazulenodipyrroles bearing alkyl substituents at the nitrogen atom showed pronounced cytotoxocity against A549 human lung adenocarcinoma cell line while N-aryl analogs were non-cytotoxic.
Keywords: 3-diazo-2-arylidene succinimides; rhodium carbene; cyclopropanation; 1,5-C‒C bond migration
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Vepreva, A.; Bunev, A. S.; Kudinov, A. Y.; Kantin, G.; Krasavin, M.; Dar'in, D. Beilstein Arch. 2022, 202217. doi:10.3762/bxiv.2022.17.v1
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