Formation of unusual unsymmetrical dimers or/and indenes via Rh2(esp)2-catalyzed decomposition of diazo arylidene succinimides has been investigated. The reaction proceeded under mild conditions, and its result was shown to strongly depend on the nature of the substituents in the diazo substrate. The new reaction provides access to dibenzoazulenodipyrrole and indenopyrrole derivatives in moderate to high yield. Dibenzoazulenodipyrroles bearing alkyl substituents at the nitrogen atom showed pronounced cytotoxocity against A549 human lung adenocarcinoma cell line while N-aryl analogs were non-cytotoxic.
Keywords: 3-diazo-2-arylidene succinimides; rhodium carbene; cyclopropanation; 1,5-C‒C bond migration
|Format: PDF||Size: 4.3 MB||Download|
When a peer-reviewed version of this preprint is available, this information will be updated in the information box above. If no peer-reviewed version is available, please cite this preprint using the following information:
Vepreva, A.; Bunev, A. S.; Kudinov, A. Y.; Kantin, G.; Krasavin, M.; Dar'in, D. Beilstein Arch. 2022, 202217. doi:10.3762/bxiv.2022.17.v1
|Download RIS (Reference Manager)||Download BIB (BIBTEX)|