Design and Synthesis of Planar Chiral Bisphosphine Ligands Based on Diphenyl [2.2]-Paracyclophane

Submitting author affiliation:
Zhejaing University, Hangzhou, China

Beilstein Arch. 2021, 202183.

Published 30 Nov 2021

This preprint has not been peer-reviewed. When a peer-reviewed version is available, this information will be updated.


Planar chiral bisphosphine ligands based on diphenyl [2.2]paracyclophane (PhPhanePHOS)  were successfully synthesized in a practical manner in four steps from commercially available 4,12-bisbromo-[2.2]paracyclophane as a new family of bisphosphine ligands. The novel PhPhanePHOS ligands provide high catalytic activity in Pd-catalyzed asymmetric allylalkylation reactions in preliminary experiments.

Keywords: asymmetric catalysis, planar chiral ligand, bisphosphine ligand, paracyclophane, asymmetric reactions

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When a peer-reviewed version of this preprint is available, this information will be updated in the information box above. If no peer-reviewed version is available, please cite this preprint using the following information:

Huang, S.; Jin, J.; Lin, X. Beilstein Arch. 2021, 202183. doi:10.3762/bxiv.2021.83.v1

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