In vivo toxicity evaluation of boron nitride nanosheets with different sizes by silkworm model

  1. Vivian Andoh,
  2. Haiyan LiuORCID Logo and
  3. Lin MaORCID Logo

Submitting author affiliation: Jiangsu University of Science and Technology, Zhenjiang, China

Beilstein Arch. 2021, 20218. https://doi.org/10.3762/bxiv.2021.8.v1

Published 28 Jan 2021

  • Preprint

Abstract

Boron nitride nanosheets (BN NSs), a novel material with great potential in biomedical applications, have attracted great attention due to its extraordinary properties. A crucial issue is the toxicity of BN NSs, which depends greatly on various factors, including size. The size may affect viability of cells due to the interactions between BN NSs and cell membranes. In this study, two kinds of silkworms (qiufeng × baiyu, Nistari 7019) were used as models to investigate the toxicity of BN NSs with different sizes (BN NSs-1: thickness of 41.5 nm, average diameter of about 200 nm; BN NSs-2: thickness of 48.2 nm, average diameter of about 500 nm) from the levels of animal entirety (silkworm mortality, silkworm growth, cocoons) and tissues. The results show that exposure to different sized BN NSs causes no obvious adverse effects on the growth or tissues of silkworm. This study has performed size-dependent in vivo toxicity evaluation of BN NSs and provided safety information to enrich the database for better application of BN NSs. Further studies should be carried out to discover the biosafety of diverse sizes and shapes BN NSs.

Keywords: boron nitride nanosheets; silkworm model; toxicity evaluation; in vivo; size effect

Supporting Information

Format: DOCX Size: 3.5 MB   Download

How to Cite

When a peer-reviewed version of this preprint is available, this information will be updated in the information box above. If no peer-reviewed version is available, please cite this preprint using the following information:

Andoh, V.; Liu, H.; Ma, L. Beilstein Arch. 2021, 20218. doi:10.3762/bxiv.2021.8.v1

Download Citation
Download RIS (Reference Manager) Download BIB (BIBTEX)

© 2021 Andoh et al.; licensee Beilstein-Institut.
This is an open access work under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0). Please note that the reuse, redistribution and reproduction in particular requires that the author(s) and source are credited and that individual graphics may be subject to special legal provisions.
The license is subject to the Beilstein Archives terms and conditions: (https://www.beilstein-archives.org/xiv/terms)

Other Beilstein-Institut Open Science Activities

Logo
Logo
Logo
Symposia