Here we present an enantioselective aminalization of aldehydes catalyzed by Brønsted acids based on pentacarboxycyclopentadienes (PCCPs). Cyclization reaction using readily available anthranilamides as building-blocks provides an access to valuable 2,3-dihydroquinazolinones containing one stereogenic carbon center with high degree of enantioselectivities (ee up to 81 %) and excellent yields (up to 97%).
Keywords: Pentacarboxycyclopentadiene; PCCP; Brønsted acid; aminalization; organocatalysis
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Kamlar, M.; Reiberger, R.; Nigríni, M.; Císařová, I.; Veselý, J. Beilstein Arch. 2021, 202148. doi:10.3762/bxiv.2021.48.v1
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