Hydrothermal synthesis of carbon nanodots from wine cork and biocompatible fluorescent probe

  1. Ngo Khoa QuangORCID Logo,
  2. Nguyen Ngoc HieuORCID Logo,
  3. Vo Van Quoc Bao,
  4. Vo Thi Phuoc,
  5. Le Xuan Diem Ngoc,
  6. Luong Quang Doc,
  7. Nguyen Minh Tri,
  8. Le Vu Truong SonORCID Logo,
  9. Le Van Thanh SonORCID Logo and
  10. Che Thi Cam Ha

Submitting author affiliation: University of Sciences, Hue University, Hue, Viet Nam

Beilstein Arch. 2021, 202145. https://doi.org/10.3762/bxiv.2021.45.v1

Published 09 Jun 2021

  • Preprint


We presented a low-cost and simple method to synthesize carbon nanodots (CDs) from waste wine cork using hydrothermal synthesis.  The structural and optical properties of the CDs are characterized by TEM, FTIR, Raman, UV-Vis absorption, and photoluminescence (PL) spectra. The analysis results indicated the average diameter of CDs ⁓ 6.2 ± 2.7 nm. Optical measurements showed the phenomenon of excitation-dependent PL and the formation of functional groups on the surface of the particles. CDs with a quantum yield of 1.54% was calculated using quinine sulfate as reference. Furthermore, a probe of wine cork-derived CDs in bioimaging has been successfully applied in living mesenchymal stem cells (MSCs). After treatment with CDs, MSCs exhibited fluorescence including green, yellow, and red colors under the excitation wavelengths in the range 330–385 nm, 450–480 nm, and 510–550 nm, respectively. The achievement demonstrated potential applications of fluorescent CDs in the field of the fluorescent image.

Keywords: carbon nanodots; hydrothermal synthesis; fluorescence; fluorescent image; waste wine cork

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When a peer-reviewed version of this preprint is available, this information will be updated in the information box above. If no peer-reviewed version is available, please cite this preprint using the following information:

Khoa Quang, N.; Hieu, N. N.; Bao, V. V. Q.; Phuoc, V. T.; Ngoc, L. X. D.; Doc, L. Q.; Tri, N. M.; Son, L. V. T.; Son, L. V. T.; Ha, C. T. C. Beilstein Arch. 2021, 202145. doi:10.3762/bxiv.2021.45.v1

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