Batch preparation and characterization of ZnO/PLGA/PCL nanofiber membranes for antibacterial materials

Submitting author affiliation:
Soochow University, Suzhou, China

Beilstein Arch. 2021, 202143.

Published 07 Jun 2021

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This preprint has not been peer-reviewed. When a peer-reviewed version is available, this information will be updated.


As biomaterials with excellent biocompatibility, biodegradation and low toxicity, poly(ε-caprolactone) (PCL) and poly(lactic-co-glycolic acid) (PLGA) are widely applied as wound dressing and surgical suture in biomedical field. In this paper, an oblique section free surface eletrospinning (OSFSE) apparatus was utilized to prepare high-quality and high-output ZnO/PLGA/PCL nanofiber membranes (NFMs) for antibacterial materials. The effects of the weight ratio of PLGA and PCL on the viscosity and conductivity of electrospinning solutions as well as the yield, morphology and wettability of PLGA/PCL NFMs were researched, and the optimal weight ratio of 6:4 was determined. Then the effects of ZnO contents on the electrospinning solution properties as well as the yield, morphology, structure, wettability, mechanical property and antibacterial performance of ZnO/PLGA/PCL NFMs with the optimal ratio of PLGA and PCL were studied. The results indicated that the addition of ZnO could improve significantly the antibacterial effect of NFMs, and the NFMs with 3 wt% ZnO had excellent antibacterial activity against E. coli (95.3%) and S. aureus (95.7%).

Keywords: high-throughput preparation; ZnO/PLGA/PCL nanofiber membranes; free surface eletrospinning; antibacterial property

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When a peer-reviewed version of this preprint is available, this information will be updated in the information box above. If no peer-reviewed version is available, please cite this preprint using the following information:

Li, S.; Yin, J.; Xu, L. Beilstein Arch. 2021, 202143. doi:10.3762/bxiv.2021.43.v1

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