Beilstein Arch. 2021, 202118. https://doi.org/10.3762/bxiv.2021.18.v1
Published 09 Mar 2021
A DBU-catalyzed Michael additions of several pronucleophiles with high pKa values including bulky glycine imines, α-tetra-lone, 1-methyl-2-indolone and nitroalkanes to α,β-unsaturated isoxazoles and pyrazolamides have been realized in THF with 1.0 eq. LiBr as a additive at room temperature within 3 h to provide Michael adducts in excellent yields (up to 97%) and diastereoselectivities (> 20:1).
Keywords: Michael addition; glycine imine; α,β-unsaturated isoxazole; α,β-unsaturated pyrazolamide; DBU
When a peer-reviewed version of this preprint is available, this information will be updated in the information box above. If no peer-reviewed version is available, please cite this preprint using the following information:
Bai, Y.-J.; Cheng, M.-L.; Hu, X.-M.; Bai, Y.-J.; Zheng, X.-H.; Zhang, S.-Y.; Wang, P.-A. Beilstein Arch. 2021, 202118. doi:10.3762/bxiv.2021.18.v1
| Download citation | |
| Download RIS (Reference Manager) | Download BIB (BIBTEX) |
© 2021 Bai et al.; licensee Beilstein-Institut.
This is an open access work under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0). Please note that the reuse, redistribution and reproduction in particular requires that the author(s) and source are credited and that individual graphics may be subject to special legal provisions.
The license is subject to the Beilstein Archives terms and conditions: (https://www.beilstein-archives.org/xiv/terms)
