Synthesis, characterization and comparative anticancer potential of phytosynthesized mono and bimetallic nanoparticles using Moringa oleifera aqueous leaf extract.

  1. Shruti GuptaORCID Logo,
  2. Hemlata HemlataORCID Logo and
  3. Kiran Kumar TejavathORCID Logo

Submitting author affiliation: CENTRAL UNIVERSITY OF RAJASTHAN, Kishangarh, India

Beilstein Arch. 2020, 202095. https://doi.org/10.3762/bxiv.2020.95.v1

Published 25 Aug 2020

  • Preprint

Abstract

In this article we bring up facile one-step phytosynthesis of Silver (Ag), Gold (Au) and Ag/Au bimetallic nanoparticles by reduction of Silver nitrate and Tetrachloroauric acid solution, using aqueous leaf extract of Moringa oleifera. Physical characterization was done using different techniques including UV-Visible spectroscopy, FT-IR Spectroscopic Analysis, DLS, Zeta Potential, XRD, TEM and EDAX. These nanoparticles were evaluated for their cytotoxicity against human hepatocellular carcinoma cells (HepG2) and breast cancer cell line (MDA-MB-231 and MCF-7). Our data suggest these phytosynthesized nanoparticles showed a dose-dependent cytotoxic effect on all the cancer cell lines. However, AuNPs is seen to have higher cytotoxic potential with IC50 value in the range of  9.20-21.46µg/ml  compared to that of Bimetallic NPs (Ag-Au NPs) with IC50 value of 37.22-49.94µg/ml. Whereas, Silver NPs (AgNPs) didn’t show cytotoxic activity upto 60µg/ml in all the three cell lines for 24hrs. Hence, this study supports the effectiveness of phytosynthesized AuNPs for the development of anticancer agents.

Keywords: Bimetallic Nanoparticles, Cytotoxicity, Gold, Moringa oleifera, Silver.

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Gupta, S.; Hemlata, H.; Tejavath, K. K. Beilstein Arch. 2020, 202095. doi:10.3762/bxiv.2020.95.v1

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