Palladium-Catalyzed Regio- and Stereoselective Synthesis of Aryl and 3-Indolyl Substituted-4-Methylene- isoquinolin-1(2H)-ones.

Submitting author affiliation:
University of L'Aquila, L'AQUILA, Italy

Beilstein Arch. 2020, 20208. https://doi.org/10.3762/bxiv.2020.8.v1

Published 14 Jan 2020

Preprint
cc-by Logo

Abstract

Cascade cyclocarbopalladation of the readily available aryl/alkyl-substituted propargylic amides containing an aryl iodide moiety, followed by Suzuki-Miyaura coupling with arylboronic acids, allowed an efficient regio- and stereoselective synthesis of tetrasubstituted-4-methylene-isoquinolin-1(2H)-ones. Moreover cascade cyclocarbopalladation, followed by reaction with 2- alkynyltrifluoroacetanilides, accomplished a double cyclization, to afford challenging 4-methylene-isoquinolin-1(2H)-ones bearing a 3-indolyl substituent, through aminopalladation/reductive elimination

Keywords: Isoquinolinones; Indoles; Palladium; Arylboronic Acids; Alkynylanilines.

Supporting Information

Format: PDF Size: 2.7 MB   Download

How to Cite

When a peer-reviewed version of this preprint is available, this information will be updated in the information box above. If no peer-reviewed version is available, please cite this preprint using the following information:

Nori, V.; Arcadi, A.; Carlone, A.; Marinelli, F.; Chiarini, M. Beilstein Arch. 2020, 20208. doi:10.3762/bxiv.2020.8.v1

Download Citation

Citation data can be downloaded as file using the "Download" button or used for copy/paste from the text window below.
Citation data in RIS format can be imported by all major citation management software, including EndNote, ProCite, RefWorks, and Zotero.

OTHER BEILSTEIN-INSTITUT OPEN SCIENCE ACTIVITIES