Cascade cyclocarbopalladation of the readily available aryl/alkyl-substituted propargylic amides containing an aryl iodide moiety, followed by Suzuki-Miyaura coupling with arylboronic acids, allowed an efficient regio- and stereoselective synthesis of tetrasubstituted-4-methylene-isoquinolin-1(2H)-ones. Moreover cascade cyclocarbopalladation, followed by reaction with 2- alkynyltrifluoroacetanilides, accomplished a double cyclization, to afford challenging 4-methylene-isoquinolin-1(2H)-ones bearing a 3-indolyl substituent, through aminopalladation/reductive elimination
Keywords: Isoquinolinones; Indoles; Palladium; Arylboronic Acids; Alkynylanilines.
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When a peer-reviewed version of this preprint is available in the Beilstein Journals, this information will be updated in the information box above. If no peer-reviewed version is available, please cite this preprint using the following information:
Nori, V.; Arcadi, A.; Carlone, A.; Marinelli, F.; Chiarini, M. Beilstein Arch. 2020, 20208. doi:10.3762/bxiv.2020.8.v1
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